Correction: S1-S3 counter charges in the voltage sensor module of a mammalian sodium channel regulate fast inactivation.

نویسندگان

  • James R Groome
  • Vern Winston
چکیده

These conditions do not provide a measure of driving force as needed for a Boltzmann fit to obtain conductance parameters of midpoint and slope factor. Therefore, we have analyzed the original dataset using the asymptote for the relative change in current amplitude to estimate driving force and plot G-V relations. G/GMAX was plotted as a function of voltage, and these curves were fit with a Boltzmann function to yield corrected values for midpoint and slope factor. These values and calculations for the change in free energy (DDGo, nzFV0.5) for mutations are provided in Table 3. Correction to plots for I-V relations given in the original paper are provided as extra panels for Figs. 2, 6, and 10. Fig. 11 has been replotted in its entirety. Table 3 and Figs. 2, 6, 10, and 11 are below.

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عنوان ژورنال:
  • The Journal of general physiology

دوره 146 6  شماره 

صفحات  -

تاریخ انتشار 2015